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Amyotrophic Lateral Sclerosis (Lou Gehrig s
Disease and Other Motor Neuron Diseases
Motor neuron diseases are
characterized by weakness and wasting of affected muscles, without accompanying sensory changes.
Werdnig-Hoffman disease and Kugelberg-Welander syndrome occur in infants or children.
Motor neuron disease in adults generally commences between 30 and 60 years of age. There is
degeneration of the anterior horn cells in the spinal cord, the motor nuclei of the lower cranial
nerves, and the corticospinal and corticobulbar pathways. The disorder is usually
sporadic, but familial cases may occur
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